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[1] demonstrated that CSE knock out (CSE KO) mice fed with atherogenic diet displayed a 30-fold increase in ICAM-1 expression and increased atherosclerotic plaque size compared to wild type control

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Protein ingestion induces muscle insulin resistance independent of leucine-mediated mTOR activation

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46,7375 It is therefore suggested that metformin use may be an agent of iatrogenic potential inducing peripheral neuropathy exacerbation in individuals with T2DM who have depressed Vitamin B12, as a result of elevated fasting methylmalonic acid (MMA) and tHcy levels

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