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Published 2018 May 25

Iron accumulation-induced ROS, such as superoxide anion (O 2 -) and hydroxyl radical (OH), possess an unpaired electron at their outer orbit which allows them to react with all cellular components including proteins, lipids and nucleic acid

Molecular docking revealed hydrogen bonds with MPOs His95 and Arg239

"Why we have to teleport disbelief"

Such coordinated signaling ensures rapid Ca 2+ uptake into the mitochondrial matrix, activation of TCA cycle enzymes, and stimulation of ATP synthesis ( 2+ fluctuations, promotes controlled secretion, and protects the cell from the spread of pathological calcium signals ( 2+ imaging, NADH autofluorescence, ATP sensors) rather than direct dynamic visualization of individual MAM microdomains, and thus cannot fully resolve the causality between structural contacts and functional responses