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6 Metabolic reprogramming in COPD experimental models 6.1 Introduction to metabolic reprogramming The process by which cells alter their metabolic pathways to meet their bioenergetic, biosynthetic, and redox needs in response to adverse environments such as hypoxia and nutrient deficiency is termed metabolic reprogramming (66)

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As a comparison, only ~1% hemolysis was observed upon treatment of mouse whole blood with LAAM GSH-CQDs at a concentration up to 5 mg mL 1 , which was close to the value of 0.5% for PBS as the negative control group (Fig