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Abbreviations ALP: Alkaline phosphatase ALT: Alanine transaminase AST: Aspartate transaminase BatF3: Basic leucine zipper ATF-like transcription factor 3 DAPI: 4,6-diamidino-2-phenylindole GSH: Glutathione EHBD: Extra hepatic bile duct IHBD: Intra hepatic bile duct MDR2: multidrug resistance protein 2 NAC: N -Acetyl-L-Cysteine PSC: Primary sclerosing cholangitis WT: Wild type ZO-1: Zonula occludens-1 References Banales, J

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Based on the p53 regulatory network, small molecule modulators or gene editing tools can be designed, and their therapeutic effects on cartilage protection and inflammation alleviation can be validated in OA animal models