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Metabolic Reprograming of Microglia in the Regulation of the Innate Inflammatory Response

L-Carnitine untuk Kesihatan Neurologi Satu bentuk karnitin yang dipanggil acetyl-L-carnitine telah dikaji untuk kesan neuroprotektif

Erickson CA, Stigler KA, Corkins MR, Posey DJ, Fitzgerald JF, McDougle CJ

NE is the trigger for the pinealocytes to produce melatonin by activating the transcription of the mRNA encoding the enzyme arylalkylamine N-acetyltransferase (AA-NAT), the first molecular step for melatonin synthesis (8) (Figure 1)

In mammals, sulforaphane can similarly upregulate stress-induced signaling pathways, including the Nuclear Factor Erythroid 2-related Factor 2 (NRF2) transcriptional pathway, which is conserved across mammalian species, but absent from plants (Gacesa et al., 2016