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(2018) 13(4):e0196405

89 It also induces a cytostatic effect on the cell cycle by deregulating extracellular signal-regulated protein kinases and subsequently suppressing cyclin E and cyclin-dependent kinase

Significantly more potent and better tolerated than arsenic trioxide, Darinaparsin showed encouraging responses in T-cell lymphoma (Hosein et al., 2012) and AML (Nielsen et al., 2013) patients

The Regulation of Ferroptosis GPX4 acts as a crucial downstream mediator of the amino acid transporter system x c , playing a vital role in ferroptosis regulation by reducing lipid hydroperoxides in membranes