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Am J Physiol Cell Mol Physiol

Lactate interacts with Akt proteins, inducing cellular senescence and oxidative stress by modulating the Akt/p21/p27/cyclin D1 and Akt/Nrf2/HO-1 signaling pathways (Zhang et al., 2024a)

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Nutrients 14 , 529

Studies have demonstrated that ALOX15 exacerbates I/R-induced brain injury [305] and ischemia-induced myocardial injury [306] by inducing PL-PUFA peroxidation and ferroptosis, suggesting the therapeutic potential of targeting ALOX15 for these I/R-induced tissue injuries