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By shuttling electrons one at a time from complexes III to IV, it serves as a crucial linker in the respiratory chain 111

This is of significant importance, as even though some patients may derive long-term benefits from immunotherapy, these patients cannot be identified upfront due to the lack of predictive biomarkers

and (iv) Be responsive to stakeholder input

Angew Chem Int Ed Engl 60(6):31213130

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