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Activation of AP-1 by mutant SOD1 in NSC-34 cells mediates upregulation of Bcl2-A1, which regulates apoptosis (Kale et al., 2018)

Also, many opiate urine drug tests use a high cutoff value, which could result in a false negative if the patient is using it infrequently (eg, as needed or once a day) or at a low dose