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R in each case 2 Independently is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, nitrogen protecting group, or a group of formula (i), (ii) or (iii)

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VEGF from a variety of cell types (including stromal cells) promotes budding through tip and stem cell formation, maintains tissue homeostasis during embryonic development and adult life, and is critical for embryonic and postnatal angiogenesis

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