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Collectively, to systematically investigate tissue- and cell-type-specific expression profiles of E3 Ub ligases, under normal or diseased/stressed states, will be an attracting topic in the next decade either to comprehensively understand the biology of E3 ligases in different diseases/stresses or to extend PROTAC applications

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Cognitive support, mood support, and bone and joint health support remain niche segments, targeting specific health concerns in targeted demographics

Key areas requiring further investigation include cumulative effects of chronic exposure, drug interactions, and impact on various organ systems