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M., Reddy, V., & Pillarisetty, L

The concomitant impact aging has on astrocytes also induces a phenotypic switch that results in altered gene expression, perpetuation of inflammation, and recruitment of peripheral immune cells, which further exacerbates inflammation (Palmer and Ousman, 2018

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and similar results have been reported in humans (Burk et al., 2006)

specific epigenetic modifications (e.g., DNA methylation and histone acetylation) that regulate ferroptosis-related genes (e.g., GPX4 and SLC7A11) in LN immune cells or renal tissue have not been systematically mapped