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GSH depletion and oxidative stress reduce the expression of IL-1, TNF- and IL-6 in LPS-induced macrophages [42]

J Nurse Midwifery 1984

Once the substrate reaches saturation, adding more substrate will not further increase the reaction rate

It becomes even harder to keep up when you add chronic stress and substances that deplete glutathione, including: Drugs containing Acetominophen Alcohol Excess body fat Smoking Low protein intake Medications: Acid blockers Analgesics Antacids Antibiotics Antivirals Tricyclic antidepressants Low Glutathione means low immune, lung, and liver function

This suggests that curcumin can support the bodys natural ability to produce glutathione, especially in conditions of oxidative stress