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Among these, progesterone resistance theory involving eutopic endometrium of women with and without endometriosis falls short of evidence and is somewhat ambiguous

The PI3K/AKT axis drives fibrotic responses via AKT/mTOR and PAK2/c-Abl signaling [43, 44], while the MEK/ERK pathway contributes to pulmonary fibrosis, particularly under Bmi-1 deficiency [45]

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In a study of patients with end stage renal impairment, mean elimination half-life was prolonged in uremic patients due to increased volume of distribution and reduced clearance