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Recently, EMR analysis has evolved beyond simple text embedding, with embedding-based approaches leveraging both structured and unstructured data to improve clinical prediction performance [25, 26]

The Phase 3 OPTIONS study (536 subjects, 24 weeks) failed to show statistically significant weight loss compared to placebo

MicroRNAs (miRNAs) have been also shown to play an important role in adipogenesis, IR, and inflammation as previously reviewed [49].Tonicity-responsive enhancer-binding protein (TonEBP), a key transcription factor involved in cellular adaptation to hypertonic stress, has been suggested to influence macrophage activity, adipogenesis, and IS by inhibiting the epigenetic transition of PPAR2 [50]

High risk populations include those who follow vegan or vegetarian diets, weight-loss surgery patients, individuals with gastrointestinal disorders and the elderly