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KD appears well positioned to intervene in this process, overlapping with broader microbiota-targeted strategiesincluding probiotics, synbiotics, FMT, and antibioticsthat are increasingly regarded as potential disease-modifying interventions in PD [129, 177]

Glutamine anaplerosis supplies glutamate, while the transsulfuration pathway provides cysteinethe rate-limiting precursor for GSH biosynthesis [57, 97]

[Accessed 27 Oct.2025] (online) Ema.omeprazole

O.AlvarezS

These pathways are coordinated by S-adenosylmethionine (SAM), which have a specific role as an allosteric inhibitor for the methylenetetrahydrofolate reductase (MTHFR) reaction and acts as an activator of cystathionine -synthase (CBS) [2]