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Progressive liver fibrosis also enhances HSC and portal fibroblast activation through matrix rigidity, creating a positive feedback loop of fibrogenesis and oncogenesis (154)

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Greenberg, A

doi: 10.1002/alz.12468 299

Interestingly, a recent clinical trial in climacteric women working fixed shifts found that low-dose exogenous melatonin administered for three months did not significantly alter dietary intake or body composition, although postmenopausal participants showed modest reductions in fat mass, suggesting that physiological melatonin doses may have limited impact on metabolic outcomes in NS workers 190