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Mol Psychiatry 30 , 237250 (2025)

The repeated finding that E-domain effects are strongest in young, growing tissue and blunted with age seen both in cultured human satellite cells [6] and in virally treated mouse muscle [21] is a particularly pointed reminder that the models most likely to show a positive result are the least representative of the adult humans who feature in performance narratives

Animal models have shown that various flavonoids or their fragments or metabolites can cross the bloodbrain barrier and provide a neuroprotective effect against cognitive impairment (Vauzour et al