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Peer review Peer review information Nature Reviews Urology thanks Ranjith Ramasamy, Elizabeth Bromfield and Kenneth Aston for their contribution to the peer review of this work

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2 Exposome The exposome (Figure 1) encapsulates all of the environmental (non-genetic) exposures experienced by an individual from an array of dietary, lifestyle, and demographic factors throughout the lifespan that impact health outcomes (Wild, 2005)