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Current EPA Guidelines Require Updated Uncertainty Factors The guidelines on risk assessment of neurotoxic agents (EPA 1998) clearly indicate that an uncertainty factor of ten should be applied when attempting to extrapolate a lowest-observed adverse-effect-level (LOAEL) to establish an REL, as is the case for studies of mercury vapor toxicity the threshold cannot be determined from available studies

To establish secondary spinal cord injury, four animals were sacrificed 10 min after spinal injury immediately prior to the administration of therapy

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