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Extensive scholarly research has shown that nitric oxide, hydrogen peroxide, hydroxyl radicals, and superoxide anion are essential components of oxidative stress, which ultimately results in Alzheimers disease (593)

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PLGA and other biodegradable carriers can readily be functionalized with GSH-cleavable linkers or redox-sensing moieties, providing clinically tractable routes to translate GSH-responsive designs into precision treatments [23]