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A landmark study of 4363 COPD patients, followed for a median of 9.5 years, found that the presence of mucus plugs in 12 versus 0 and 3 versus 0 lung segments was associated with adjusted hazard ratios for all-cause mortality of 1.15 and 1.24, respectively [10]

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**Valoarea nutritionala de referinta, conform Reg

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Specifically, EVNs target and block the infiltration of peripheral inflammatory cells via the CCR2CCL2 axis, while the released DT activates the Nrf2GPX4 pathway, inhibiting microglial ferroptosis and neuroinflammation, thereby promoting a shift toward an anti-inflammatory phenotype