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Sexual differences in responses to APAP

Glutathione is a tripeptide (containing 3 amino acids: cysteine, glutamic acid, and glycine) naturally made in human cells that functions as a powerful antioxidant

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DECLARATIONS Authors contributions Developed the model, ran simulations and analyses, interpreted the findings, and contributed to the writing and editing of the manuscript: Cruikshank A, Reed MC, Nijhout HF Availability of data and materials Computer models and codes used in this paper can be obtained from the authors by request

This response is partially mediated by CGRP and/or CSD, and involves oxidative stress, mitochondrial dysfunction, the assembly of NLRP3 inflammasomes, activation of microglia, and the reactivity of astrocytes