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Figure 2 Bioavailability Enhancement: A hallmark of PPR is its ability to augment the bioavailability of drugs and nutrients

It has been demonstrated that pro-inflammatory and pro-fibrotic factors such as TGF- and TNF- play a considerable role in asthma pathogenesis (Janulaityte et al., 2020

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

Table 1 shows the pharmacological properties and practical advantages of these agents relative to Erastin, providing a reference framework for selecting candidates and delivery strategies in preclinical models of EMS

This contrasts with certain immunotherapies, such as nivolumab, which can lead to serious immune-related adverse events including cholangitis (169)