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Remodelling the extracellular matrix in development and disease

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Despite the numerous challenges associated with the evolution of multi-omics technologies, the maturation of 3D culture models, and advancements in biosensor technologies, exploring metabolic alterations and regulatory signals under pathological cardiac conditions in vitro holds promise for further elucidating the molecular mechanisms of diseases

The obtained results showed that everolimus and metformin cooperate to inhibit mTOR activity, tumor cell growth and colony formation, independently of glucose and O 2 concentrations (214)