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At the molecular level, both alterations in lipid metabolism and disturbances in glucose metabolism meet in the citrate cycle running inside the mitochondria and thus adversely affect their function

CHAC1 degradation of glutathione enhances cystine-starvation induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2-ATF4 pathway

doi: 10.1016/s0076-6879(96)68031-8

These findings not only illuminate the molecular link between ferroptosis and tumor immune evasion but also suggest a potential therapeutic strategy of combining ferroptosis inducers with immune checkpoint inhibitors (ICIs) for HPV-negative HNSCC

TABLE 7 In vivo -Studies using ICR mice