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When this occurs, the odor is usually described as unpleasant

For the entire 20th century, it is estimated that around 100 million people died prematurely because of smoking, most of them in rich countries

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Further, since epidemiological studies have consistently shown high rates of concurrent use of multiple tobacco products [34,35,36], therefore the impact of concurrent exposures to two products (HTPs plus combustible cigarettes and HTPs plus e-cigarettes) on pulmonary health needs to be evaluated and compared to exclusive exposure to alternative tobacco product and abstinence from all tobacco products