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This forms a self-perpetuating cycle of iron-induced -syn aggregation and neuronal damage, exacerbating PD progression (Fig

doi: 10.1016/bs.vh.2021.11.009 18 BelfioreAMalaguarneraRVellaVLawrenceM

Rikjer, J

Biosynthesis of 25hydroxycholesterol in macrophages is stimulated by the endotoxin Kdo2-lipid A, the component of the lipopolysaccharide present on the outer membrane of Gram-negative bacteria, which acts as an agonist for Toll-like receptor 4 (TLR4)