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84, 89 In addition to the PCD in single cell protists, elegant studies in Leishmania spp , and Leishmania amazonensis , have led to a conceptual distinction between apoptotic death (in which the organism dies) and apoptotic mimicry (in which the organism mimics death to favor infectivity)

In contrast, under oxidative stress conditions, ubiquitin ligase activity is blocked by modifying the cysteine residues in Keap1, thereby stabilizing and activating (Noguchi et al., 2018), stable NRF2 then translocates into the nucleus, binds to antioxidant response elements in the gene promoter region and regulates the transcription of a range of target genes involved in antioxidant defense and cellular redox maintenance (Ooi et al., 2018

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Mesalazine positive control (5-ASA) group: subjected to DSS modeling

CaMK1 plays multiple roles in neuronal development and plasticity and is required for the regulation of axonal outgrowth and growth cone morphology, dendritic branching, and formation of dendritic spines and synapses [94,95,96,97,98]