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Heneka et al., 2015

Nevertheless, further investigations into the structures, pharmacological effects, and mechanisms underlying H

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( See article Addition Reactions Eliminations Opposite) Here is an example of a Michael reaction between the enolate of a malonic ester and an alpha, beta-unsaturated ketone ( aka enone ) where a strong base (NaOCH 3 in this case) is used to form the enolate: (The pK a of malonic esters is usually around 13, so this is quite a favorable acid-base reaction) A new C-C single bond is formed, and so is a new C-H bond on the alpha-carbon of the alpha, beta unsaturated ketone