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Once this antiinflammatory structure (in our model the AIregion) is established, newly recruited cells polarize according to the region they arrive in thereby reinforcing the character of this specific inflammatory region (Chen et al , 2020)

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For example, PHGDH promotes immune escape in tumor cells but suppresses antitumor T-cell immunity in endothelial cells, revealing cell-type-specific functional dichotomy of the SSP ( Microenvironmental dynamics: Biophysical cues including extracellular matrix stiffness modulate serine synthesis by regulating glycolysis, but the underlying molecular mechanisms remain poorly defined, limiting the development of combined strategies targeting both metabolism and the tumor microenvironment

B: Enzymatic