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This disruption occurs through multiple mechanisms, including direct androgen receptor antagonism, altered steroidogenesis, and interference with androgen-regulated gene expression patterns

Moreover, the induction of ferroptosis can enhance the effects of radiotherapy, increasing tumor cell sensitivity and improving treatment outcomes

Kao T, Lin C, Yang W, Li H, Hsu T

In multiple myeloma, GOT1 expression was inhibited by shikonin, enhancing ferroptosis in multiple myeloma cells by promoting the release of autophagic labile iron (21)

FIGURE 1 2.2.4 Other metabolic pathways Mitochondria play an essential role in the advancement and development of ferroptosis (Zhang et al., 2021)