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Alternatively, there may be native FBXO22 substrates that are potentially recruited to the E3 ligase via engagement of Cys326 in a similar fashion to our NSD2 degraders that have not yet been uncovered

J Clin Invest 111:785793 Dvila D, Torres-Aleman I (2008) Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor I signaling

Full therapeutic benefits typically manifest within 4-8 weeks of consistent treatment

Targeting macrophages rescues age-related immune deficiencies in C57BL/6J geriatric mice