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First, LMP1 is able to interact with both receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3) by C-terminal activation region 2 (CTAR2), which is necessary for this interaction

Mansur Molecular Psychiatry.2026

However, our study did not directly assess mitochondrial function or ROS levels, and thus, this mechanism remains speculative

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Moreover, emodin may act by antagonizing the P2X7 receptor, thereby decreasing the activation of M1 macrophages and potentially inhibiting their recruitment to the tumor microenvironment [450]