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Since there are no crystal structures of the Nrf2/MafG interaction available to guide the design of the Nrf2 peptides, they utilized AlphaFold to predict the structure of the Nrf2/MafG heterodimer, then used the AlphaFold model to determine the best region to target for inhibition and designed three 16-amino-acid peptides that cover the predicted binding domain, they also used the model to determine the best locations for staples, specifically focusing on locations unlikely to interrupt the binding of the N1S to MafG

We talk about where the line should be, why Jill's ALMOST lowkey feeling bad for Amanda (??), and how important solid friendships areespecially when things get messy

From the studies discussed above, it seems that cooking with oil at temperatures of 180C generates substantial amounts of acrolein (5-250 mg/kg oil) that is released into the atmosphere

Dairywala MI, Gupta S, Y Luc JG, Mughal A, Antonoff MB, C Nguyen AT

E., Sanchez-Martinez, A., Delgado-Camprubi, M., Ivatt, R