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Subsequent studies confirmed senolytic activity in additional cell types including chondrocytes, Leydig cells, keloid fibroblasts, and endothelial cells demonstrating that the FOXO4-p53 dependency is a conserved feature across multiple senescent cell populations

J Biol Chem 279: 2228493

Glutathione synthetase deficiency is the most frequently recognized disorder of GSH metabolism, although it is also a comparatively rare disease (Njalsson and Norgren, 2005

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