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Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function

For example, combining ROR1-targeted CAR-T cells with ferroptosis inducers enhances lipid peroxidation and augments antitumor efficacy in a mouse model of NSCLC (107)

Emerging human-relevant systemssuch as patient-derived BBB-on-chip and organoid platformsare beginning to bridge this divide, revealing that PD astrocytes can impair barrier integrity and neurovascular signaling ( in vivo biomarkers and mechanistic clinical studies are still needed to determine whether these pathways function similarly in human PD and to guide the development of targeted neurovascular interventions

References Farquhar CM: Endometriosis

Free Radic Biol Med 46:965988