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Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus

For instance, chronic high H 2 O 2 levels can activate p38 continuously, inducing melanocytes to premature senescence (dysfunctional) and susceptible to apoptosis ( FIGURE 7 Vitiligo patients have a reduced mitophagy process in epidermal melanocytes (Vainshtein et al., 2015)