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Compared with non-smokers, primary ATII cells from patients with COPD exhibited diverse structural changes, such as reduced mitochondrial area and perimeter, and impaired mitochondrial cristae arrangement

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Studies have shown that neuromuscular electrical stimulation could promote muscle protein synthesis, increase muscle mass and improve diaphragm muscle strength and fatigue resistance (Maddocks et al., 2016), especially for patients with moderate and severe COPD with limited exercise capacity

their activation is effective against nociceptive and neuropathic pain (Zammataro et al., 2011