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244 In vascular smooth muscle cells, ROS activate c-Abl, which phosphorylates PKC (Tyr512/523), 245 leading to PYK2 phosphorylation (Tyr402/579) and subsequent JAK2 transphosphorylation

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253 A pivotal event in CRC development is the accumulation of oncogenic -catenin due to disruptions in its regulatory pathways