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All the Figures including the graphical abstract and the schematic diagrams were created with BioRender.com. Acknowledgements We would like to thank Dr

On the other hand, there is no evidence that acute or subchronic exposure to toluene promotes the degeneration of the nigrostriatal dopamine system (Lock et al., Nanoparticles and PD Nanoparticles are an important alternative in the development of treatment strategies for neurodegenerative diseases due to their small particle size, large surface and high drug loading efficiency, which allow them to cross the blood-brain barrier and efficiently release specific drugs (Li et al., Although some NPs are being used in therapies for PD, no epidemiological studies are available associating them with PD risk

But often, a hidden culprit is a vitamin B12 deficiency causing a specific type of anemia

The age-related decline in cellular respiration further exacerbates mitochondrial electron leakage and ROS production, thereby intensifying intracellular oxidative stress

Examples include inflammatory bowel disease models, tumor microenvironments, and in vitro T cell polarization systems [62, 63, 65]