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doi: 10.1113/jphysiol.2009.179325 59 LuHHuangDSaederupNCharoIFRansohoffRMZhouL

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Using theoretical calculations and pseudo-ternary phase diagrams, we designed and constructed a thermodynamically stable ionic liquid (IL)-based microemulsion (IL-M), which integrates the high drug solubility of ILs and high skin permeability of microemulsions, thus improving the local delivery of copper peptides by approximately three-fold while retaining their biological function