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One-carbon unit supplementation fuels purine synthesis in tumor-infiltrating T cells and augments checkpoint blockade

doi: 10.2174/09298673113209990022 59 HarhajNSFelinskiEAWolpertEBSundstromJMGardnerTWAntonettiDA

In response to the Dufault et al finding, the Corn Refiners Association stated in a news interview that the findings were outdated because they no longer use mercury cell chlor-alkali products in their manufacturing process [57]

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Prolonged mitochondrial Ca overload triggers opening of the mitochondrial permeability transition pore (mPTP), causing increased membrane permeability, loss of membrane potential, mitochondrial swelling, membrane rupture, and further ATP depletion