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For gut-only protocols, the standard acetate works fine because local contact with the intestinal lining matters more than systemic uptake

A typical preventive regimen is 1,000 mcg administered intramuscularly once monthly, though some patients benefit from more frequent dosing depending on baseline status and symptoms

The dissolved oxygen concentrations in bottom water were higher in May and June than in July

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Ethics declarations Ethics approval and consent to participate The study was approved by the Ethics Committee of Renmin Hospital, Hubei University of Medicine (Ethical Approval Number: SYSRMYY-067), and informed consent forms were obtained from all couples