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86 We believe that the fabrication of microgels or microspheres through a special process and then 3D printing to create structurally specific material scaffolds for IVDD treatment is a very promising strategy

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Preclinical studies have demonstrated no significant toxicity even at doses far exceeding therapeutic ranges

doi: 10.3389/fphar.2022.995597 Received 19 July 2022 Accepted 22 August 2022 Published 23 September 2022 Volume 13 - 2022 Edited by Harvey Ho, University of Auckland, New Zealand Reviewed by Lars Ole Schwen, Fraunhofer Institut fr Bildgesttzte Medizin (MEVIS), Germany Wu Dong, Inner Mongolia University for Nationalities, China Updates Copyright 2022 Maeda, Hagimori, Sugimoto, Sakai and Nishikawa

Abbreviations, HMs, heavy metals