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30 Daily smokers have also reported greater spontaneous pain intensity after 12 to 24 hours of nicotine deprivation, 11,57 and it has been suggested that deprived states may increase pain through both central (eg, enhanced excitability of spinal dorsal horn neurons, release of pain-related neurotransmitters, and nAChR availability) and peripheral (eg, vasodilation caused by neuropeptide release from peripheral C-fiber activation) processes

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Smoking is also an established risk factor for many other chronic conditions, like lung cancer and cardiovascular disease

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