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In our sample, 15 patients (37%) had at least a mild-to-moderate depression, and nine patients were on chronic antidepressant therapy

Unlike conventional sedatives, DSIP tends to normalize sleep architecture without next-day grogginess

These are metformin and insulin sensitizing drugs (thiazolidinediones)

Sphingosine-1-phosphate alleviates colitis by regulating macrophage polarization and PI3k-Akt signaling

Dysregulation of the HPA axis is a well-established feature of depression, and the interplay between stress, alcohol use, and mood disorders underscores the need for a comprehensive understanding of these mechanisms (Stephens and Wand 2012)