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In Figure 2, we compare the redox status in the serum of women without (control) or with a mood disorder and did not observe any statistical difference in reactive species analyses (Figure 2A), SOD activity (Figure 2B), and glutathione reduced (Figure 2C)

As negative regulators of the mTORC1 pathway (Budanov and Karin, 2014), a positive regulator for nutrient-sensing of this pathway, under leucine deprivation

269 These findings illustrate that PERK signaling exerts dose-, duration-, and context-dependent effects, complicating efforts to therapeutically manipulate this pathway

doi: 10.3390/bioengineering8010003

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