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These signalling pathways are activated by the binding of different ligands to their specific melanocyte cell surface receptors (Figure 3)

In addition, this growth factor directly affects neuronal cells, and dysregulation of its expression has been implicated in several neurodegenerative diseases [172]

One possible interpretation is that p53 may act as a monitor of the intracellular copper concentration, on the one hand, to maintain a proper physiological copper level by preventing accumulation of excessive labile copper, and on the other hand, to eliminate copper-damaged cells when the uptake or level of copper is pathologically or experimentally upregulated

Levine, M., Rumsey, S

3.3 Platinum-based nanomaterials Platinum drugs, including cisplatin, oxaliplatin, and carboplatin, play an indispensable role in current cancer treatments