dihexa human clinical trials data 20mg Qty25 – NewBioRx DIHEXA 10MG : COA Tested

Gastroenterology 147 , 11341145.e10 (2014)

Methylcobalamin (B12) - 500 microgram recommended sublingual to help regenerate the active folate due to the necessary methyl group

The B12 used in fortified foods and supplements it is not bound this way and so is easier to absorb

In the first enzyme reaction, methylcobalamin is used to recycle the folate cofactor 5-methyltetrahydrofolate to tetrahydrofolate thereby allowing the folate cofactor to participate in a cycle involving the biosynthesis of purines and pyrimidines

Also, the cross-over design of the study may not be most appropriate to answer the study question given that cobalamin could be stored in the liver for a long time up to 2 to 3 years